Skip to main content

/Blog / Restylane and Perlane — a Tale of Two Fillers

Restylane and Perlane — a Tale of Two Fillers

Facial FillersDermal fillers are true to their name — they fill in a wrinkle or crease from beneath, pushing the skin back upward. Some fillers use naturally occurring hyaluronic acid to bind with water and plump up the area. Others use synthetic substances such as calcium microspheres to add supporting structure.

It’s easy to think of fillers as a new thing with the current cultural accent on looking younger. But fillers aren’t a new concept. It is thought that German physician Franz Neuber was the first doctor to use fillers. Neuber used a patient’s autologous fat taken from other areas of the body to fill out depressed facial defects. That was way back in the late 19th century!

Today, new fillers are coming to the market all the time. At Dr. Malamet’s our patients can sometimes be a little confused about what fillers do what. That’s understandable, but it is important to know that most fillers were designed for specific areas of the face. There isn’t a “general” filler.

Dr. Malamet uses a good deal of both Restylane and Perlane. Both are made by the same company, QMed. And both are hyaluronic acid fillers. But they aren’t intended for the same usage.

Here’s the difference between the two.


The main difference is consistency. Perlane is three times thicker than Restylane. Because it is thicker, Perlane can potentially be seen under the skin after it is injected. So, Perlane needs to have fat in the injection sites to help hide the filler. Its thickness makes Perlane efficient for adding volume to the cheeks, chin, and nasolabial folds. Perlane is designed for moderate to severe folds. And its results last around 18 months.


Restylane has been used much more than Perlane: it has been injected over 11 million times. As mentioned above, it is much thinner in consistency than Perlane. This allows Restylane to flow and spread out when injected. This makes it effective for defining the lip edges or filling the hollows under the eyes. Restylane works well in areas with thinner skin. Restylane results last about one year.

Now that you’re a Restylane/Perlane expert, maybe one of both of them can help you turn back the clock a little bit? Call Dr. Malamet at 818-380-3130 to make an appointment.